Covid-19 vaccine: four years later, the list of persistent symptoms is growing

Guillain-Barré syndrome (GBS)

• What: Progressive muscle weakness and numbness; can be severe.

• Which vaccines: Signal stronger for adenoviral-vector vaccines (e.g., AstraZeneca / Vaxzevria, Johnson & Johnson) in several studies; less signal for mRNA vaccines.

• How common: Rare — observed increases in some datasets within ~6 weeks after vaccination; absolute numbers are small but statistically detectable in large cohorts.

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